Hotel Twenty One is a modern 4-star hotel in Rome, the ideal place to spend an unforgettable stay in the Eternal City.

In one of the most sought-after corners of the capital, our hotel is characterized by a modern and elegant décor, comfortable surroundings and a family atmosphere. Hotel Twenty One has 93 rooms furnished to perfection and equipped with all the services you are likely to need.

A stone’s throw from the Vatican, with a picturesque view of the Pincian Hill and the dome of St. Peter’s, our 4-star hotel is in a strategic position to reach all of Rome’s main points of interest. From Hotel Twenty One you can easily explore the renowned beauty spots of Rome on foot, from the Vatican Museums to the Spanish Steps, from Piazza Navona to the Trevi Fountain, with itineraries that are unique in their combination of art, history and culture. Thanks to the nearby underground station, you can also move easily and quickly to the most fashionable streets of the capital for exclusive shopping in the boutiques of Rome.